Pharmachologic effect Azab 100
The macrolide antibiotic is a representative of azalides Azab 100. Possesses a wide range of antimicrobial action. The mechanism of action of azithromycin is associated with the suppression of microbial cell protein synthesis. By binding to the 50S subunit of ribosomes, it inhibits peptide translocation at the translation stage, inhibits protein synthesis, and slows the growth and reproduction of bacteria. Acts bacteriostatic. In high concentrations has a bactericidal effect.
It has activity against a number of gram-positive, gram-negative, anaerobic, intracellular and other microorganisms.
Contraindications
Hypersensitivity, diseases of the liver and kidneys, age up to 6 months (as a suspension), age up to 12 years with body weight less than 45 kg (oral administration in the form of tablets), age up to 16 years (infusion).
Carefully:
Predisposition to arrhythmias and prolongation of the QT interval, arrhythmia.
Side effects
Since the cardiovascular system: chest pain, palpitations.
From the side of blood: neutropenia, leukopenia, thrombocytopenia, eosinophilia, transient neutrophilia.
On the part of the urogenital system: candidiasis, vaginitis, nephritis, an increase in residual urea nitrogen.
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