Megamentin 375

Composition

Active ingredients Megamentin 375: amoxicillin (in the form of trihydrate) – 250 mg; clavulanic acid (in the form of potassium salt) – 125 mg.

Excipients: magnesium stearate – 6.5 mg, sodium carboxymethyl starch – 13 mg, colloidal silicon dioxide – 6.5 mg, microcrystalline cellulose – 650 mg.

The composition of the film shell: titanium dioxide – 9.63 mg, hypromellose (5cP) – 7.39 mg, hypromellose (15cP) – 2.46 mg, macrogol 4000 – 1.46 mg, macrogol 6000 – 1.46 mg, dimethicon – 0.013 mg.

pharmachologic effect

Augmentin – a broad spectrum antibacterial, bactericidal.

Pharmacodynamics

Amoxicillin Megamentin 375 is a semisynthetic broad-spectrum antibiotic that has activity against many gram-positive and gram-negative microorganisms. At the same time, amoxicillin is destroyed by beta-lactamases, and therefore the spectrum of amoxicillin activity does not extend to microorganisms that produce this enzyme.

Clavulanic acid, a beta-lactamase inhibitor structurally related to penicillins, has the ability to inactivate a wide range of beta-lactamases found in microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is sufficiently effective against plasmid beta-lactamases, which most often cause resistance of bacteria, and less effective against chromosomal beta-lactamases of the 1st type, which are not inhibited by clavulanic acid.

The presence of clavulanic acid in the Augmentin® preparation protects amoxicillin from destruction by beta-lactamase enzymes, which makes it possible to extend the amoxicillin antibacterial spectrum.

Below is the in vitro combination of amoxicillin with clavulanic acid.

Bacteria usually sensitive to the combination of amoxicillin with clavulanic acid

Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus spp., Incl. Streptococcus pyogenes1,2, Streptococcus agalactiae1,2 (other beta-hemolytic streptococci) 1,2, Staphylococcus aureus (methicillin-sensitive) 1, Staphylococcus saprophyticus (sensitive to methicillin), coagulase-negative strictions, and coagulant-acne-stricococcus saprophyticus (sensitized to methicillin), and coagulase-negative stitching, and coagulants, and acaconokos, and co-curriculum skatercococci, susceptible and active, and coagulase-negative stitches, and coagulacnerocococcus saprophyticus (sensitive to methicillin);